R16 is indicated for throbbing pain in the head which is usually occurs on one side accompanied by nausea and blurred vision (migraine), nervous headaches, neuralgia of the head, indisposition due to continuous headaches frequently due to cold conditions. R16 is also useful for Hemicrania (Headache on one side of the head), Occipital neuralgia (chronic pain in the back of the head, upper neck, and behind the eyes due to occipital nerves).